Tiny flash memory drives that fit on a keychain (sometimes called thumb drives) are inexpensive and convenient for transferring files between computers that aren’t on the same network–but they can also present a security risk for your organization. They can be used to bring viruses and unauthorized software in, or to smuggle sensitive information out. Luckily, there are software products, such as GFI’s Portable Storage Control (PSC), that let you control the use of these devices on your network. For more information on how it works, see www.windowsecurity.com/articles/Review-GFI-LANguard-Portable-Storage-Control.html.
Also remember that you can disable the auto play feature for USB and CD/DVD through your local or domain group policy.